Focal seizures are usually the initial seizure type, with features referable to the location of the ganglioglioma; this is most commonly temporal in location. If focal seizures do not have motor features, they may be difficult to detect in infants and young children.

Focal to bilateral tonic-clonic seizures can occur, these may have focal features if this information is carefully sought.

Epileptic spasms may occur; these may have focal features that are referable to the location of the ganglioglioma.

Status epilepticus, including focal status epilepticus, can occur, but is uncommon.

CAUTION patients with ganglioglioma, who have earlier age of seizure onset, may have a change in their seizure types over time, with the emergence of epileptic spasms or generalized seizure types, such as atypical absence, atonic and tonic seizures. Developmental and cognitive impairments are more common in this group. If these seizure types are seen, achieving full seizure control is important, if this is not achieved with medication, epilepsy surgery should be considered.

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