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GANGLIOGLIOMA

GENETICS

PATTERN OF INHERITANCE
Occurs by chance, possibly due to de novo acquired somatic gene abnormality.
KNOWN GENES

Genetic causes for gangliogliomas are not yet known. There are rare reports of gangliogliomas co-occurring with neurofibromatosis type 1, neurofibromatosis type 2, Down syndrome, Turcot syndrome, Fragile X syndrome and Peutz-Jegher syndrome. It is unknown if these rare reports of co-occurrence are by chance or suggest a genetic cause for gangliogliomas.

FAMILY HISTORY

A family history is not expected due to sporadic occurrence, genetic abnormalities if present, are likely acquired somatic genetic abnormalities, without risk of transmission to offspring.

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