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FEBRILE SEIZURES PLUS, GENETIC EPILEPSY WITH FEBRILE SEIZURES PLUS

GENETICS

PATTERN OF INHERITANCE

Inheritance in genetic epilepsy with febrile seizures plus is typically autosomal dominant with incomplete penetrance, although other inheritance patterns are recognized (see PCDH19 for example). Complex inheritance may also occur.

KNOWN GENES

A number of genes have been linked to this epilepsy syndrome including: SCN1A, SCN1B, GABRG2 and PCDH19.

FAMILY HISTORY OF SEIZURES/EPILEPSY

Family members in affected families may have febrile seizures, febrile seizures plus, genetic epilepsy with febrile seizures plus, however more severe syndromes (such as Dravet syndrome or epilepsy with myoclonic-atonic seizures) may occur due to common genetic etiologies for these different syndromes.

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