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CHILDHOOD EPILEPSY WITH CENTROTEMPORAL SPIKES

GENETICS

PATTERN OF INHERITANCE

Siblings may show the EEG trait of centrotemporal spikes in an age-dependent autosomally dominant inherited fashion without clinical seizures. The clinical epilepsy syndrome is however likely complex in inheritance as pedigrees with the clinical syndrome are very rare.

KNOWN GENES

GRIN2A

FAMILY HISTORY OF SEIZURES/EPILEPSY

Although ~10% of cases have a first-degree relative who also has epilepsy, it is rarely childhood epilepsy with centrotemporal spikes.

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