ILAE Logo
Epilepsy Diagnosis Logo

CHILDHOOD EPILEPSY WITH CENTROTEMPORAL SPIKES

GENETICS

PATTERN OF INHERITANCE

Siblings may show the EEG trait of centrotemporal spikes in an age-dependent autosomally dominant inherited fashion without clinical seizures. The clinical epilepsy syndrome is however likely complex in inheritance as pedigrees with the clinical syndrome are very rare.

KNOWN GENES

GRIN2A

FAMILY HISTORY OF SEIZURES/EPILEPSY

Although ~10% of cases have a first-degree relative who also has epilepsy, it is rarely childhood epilepsy with centrotemporal spikes.

Feedback | Home | Contact Us | Privacy | Terms & Conditions of Use | Log In For Videos
Creative Commons License
This website is owned by the International League Against Epilepsy. Text on this website, last updated July 15, 2022,
is available under a Creative Commons Attribution-ShareAlike 4.0 International License,
EXCEPTING all videos and images, which remain copyrighted by the International League Against Epilepsy.