There are numerous genetic causes of polymicrogyria, most occur de novo. In familial cases, all patterns of inheritance have been reported, however X-linked is the commonest pattern of inheritance. Polymicrogyria may also be acquired as a consequence of injury to the developing brain (e.g. CMV infection, hypoxia-ischemia).
22q11.2 deletion syndromes (including DiGeorge syndrome)
May be present (see above).