Hippocampal sclerosis is an acquired abnormality.
Not applicable in most cases - hippocampal sclerosis is an acquired abnormality. However, febrile seizures, especially if prolonged, can cause hippocampal sclerosis. Genetic epilepsies that are associated with febrile seizures (such as Dravet syndrome, Febrile Seizures Plus) can therefore predispose an individual to the development of hippocampal sclerosis.
This may be present if there is a genetic co-occurring condition associated with prior febrile seizures (see above).