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DNET

GENETICS

PATTERN OF INHERITANCE
Occurs by chance, possibly due to de novo acquired somatic gene abnormality.
KNOWN GENES

Genetic causes for DNET are not yet known. Molecular genetic studies of DNET tissue have shown a loss of heterozygosity 1p/19q in a proportion of tumors studied. There are rare reports of DNET co-occurring with neurofibromatosis type 1 (including a patient with multiple DNETs). There are rare reports of DNET co-occurring in XYY syndrome. It is unknown if these rare reports of co-occurrence are by chance or suggest a genetic cause for DNET.

FAMILY HISTORY

A family history is not expected due to sporadic occurrence, genetic abnormalities if present, are likely acquired somatic genetic abnormalities, without risk of transmission to offspring.

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