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AUTOSOMAL DOMINANT NOCTURNAL FRONTAL LOBE EPILEPSY

GENETICS

PATTERN OF INHERITANCE

An autosomal dominant inheritance pattern is seen with variable penetrance. De novo cases may occur.

KNOWN GENES

Genetic causes include nicotinic receptor subunit genes (CHRNA4, CHRNB2, CHRNA2) and DEPDC5.

FAMILY HISTORY OF SEIZURES/EPILEPSY

A family history of epilepsy is present in familial cases, with seizure features and severity varying in individuals in families.

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