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SUBCORTICAL BAND HETEROTOPIA

GENETICS

PATTERN OF INHERITANCE

The pattern of inheritance depends on the gene abnormality. LIS1 is typically an acquired gene abnormality. DCX is inherited in an X-linked pattern.

KNOWN GENES
  • DCX - accounts for most cases of subcortical band heterotopia, with the heterotopia being bilateral, symmetric and anterior predominant, with a female predominance.
  • LIS1 - posterior predominant subcortical band heterotopia
FAMILY HISTORY

May be present (see above).

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