SUBCORTICAL BAND HETEROTOPIA
PATTERN OF INHERITANCE
The pattern of inheritance depends on the gene abnormality. LIS1 is
typically an acquired gene
abnormality. DCX is
inherited in an X-linked pattern.
- DCX - accounts for most cases of subcortical band
heterotopia, with the heterotopia being bilateral, symmetric and
anterior predominant, with a female predominance.
- LIS1 - posterior predominant subcortical band
May be present (see above).